Here you can view statαlpha's Qualifications, References and Publications.

Here you will find information about statαlpha's experience, qualifications, and the company goals for providing customers with the high quality statistical services for their projects.

About the Company

statαlpha was established in 2012 and is based in the Toulouse area of France. The owner and founder, Martin Kappler, works since 2000 as a biostatistician for the pharmaceutical industry, CROs and public research in a large variety of domains such as oncology, cardiovascular, immunology, ophthalmology as well as functional food and cosmetics. Martin Kappler holds a PhD in biostatistics and a Master’s degree in statistics, specialisation biometry and regularly attends professional training. He is co-author and author of numerous publications, presentations and posters.

He has experience within clinical development in the pharmaceutical industry as well as within contract research organisations (CRO), providing support for clinical trials throughout all developmental stages of the trials from concept to submission. Martin Kappler has worked as a consultant for several international companies both on site and remotely. The wide array of services offered by statαlpha is indicative of a company seeking to bring its knowledge and experience to bear for the profit of successful and scientifically sound trials.

Biostatistics is a fast moving area with lots of new methods and designs for clinical trials in the last decade. Working as a biostatistician requires a comprehensive methodological education and up-to-date knowledge of the current developments as well as good problem solving and organisation skills. These qualities are what statαlpha is recognised for. statαlpha believes that it is vital for their customers to be presented with high quality results from their clinical trials and/or research projects.

Why choose statαlpha?

  • statαlpha is built on a sound scientific and methodological education.
  • statαlpha has a long experience working for the pharmaceutical industry, CROs and public research.
  • statαlpha has experience in a wide variety of medical domains.
  • statαlpha is highly customer orientated.
  • statαlpha implements a strict quality control policy, enabling them to ensure the highest quality standard for their customers.
  • statαlpha continually develops new services and training programs for customers.

If you would like to know more about statαlpha or if you have any questions regarding the company, the services and offers or alternatively, if you would like to get a quote on a a specific project, please feel free to fill out the contact form here or call during office hours.


statαlpha's founder and owner, Martin Kappler, has numerous academic and professional qualifications in the field of biostatistics.

    Academic Qualifications

  • PhD in Biostatistics (Please click here to download the PhD thesis)
  • MSc Statistics, specialisation biometry
  • Professional Training

  • Group Sequential Designs with Time to Event Endpoints
  • Data Monitoring Committees
  • Professional Project Management
  • Applied Statistics in Biopharmacy
  • Adaptive trials
  • Bayesian adaptive designs
  • Role and applicability of data mining in drug development
  • Advanced statistical methods in exposure assessment
  • SAS-Macro Programming


  • Dahmann D, Taeger D, Kappler M, Büchte S, Morfeld P, Brüning T, Pesch B. Assessment of exposure in epidemiological studies: the example of silica dust. J Expo Sci Environ Epidemiol 2008, 18(5): 452-61
  • Go To Publication
  • Pesch B, Kappler M, Straif K, Marczynski B, Preuss R, Rossbach B, Rihs HP, Weiss T, Rabstein S, Pierl C, Scherenberg M, Adams A, Käfferlein HU, Angerer J, Wilhelm M, Seidel A, Brüning T. Dose-response modeling of occupational exposure to PAH with biomarkers of exposure and effect. Cancer Epidemiol Biomarkers Prev 2007, 16(9): 1863-73
  • Go To Publication
  • Gratias S, Rieder HC, Ullmann R, Klein-Hitpass L, Schneider S, Boloni R, Kappler M, Lohmann DR. Allelic loss in a minimal region on chromosome 16q24 is associated with vitreous seeding of retinoblastoma. Cancer Research 2007, 67: 408-16
  • Go To Publication
  • Raulf-Heimsoth M, Pesch B, Schott K, Kappler M, Preuss R, Marczynski B, Angerer J, Rihs HP, Hahn JU, Merget R, Bruning T. Irritative effects of fumes and aerosols of bitumen on the airways: results of a cross-shift study. Arch Toxicol 2007, 81(1): 35-44
  • Go To Publication
  • View a full list of publications here.