Publications

• Dahmann D, Taeger D, Kappler M, Büchte S, Morfeld P, Brüning T, Pesch B. Assessment of exposure in epidemiological studies: the example of silica dust. J Expo Sci Environ Epidemiol 2008, 18(5): 452-61
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• Pesch B, Kappler M, Straif K, Marczynski B, Preuss R, Rossbach B, Rihs HP, Weiss T, Rabstein S, Pierl C, Scherenberg M, Adams A, Käfferlein HU, Angerer J, Wilhelm M, Seidel A, Brüning T. Dose-response modeling of occupational exposure to PAH with biomarkers of exposure and effect. Cancer Epidemiol Biomarkers Prev 2007, 16(9): 1863-73
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• Gratias S, Rieder HC, Ullmann R, Klein-Hitpass L, Schneider S, Boloni R, Kappler M, Lohmann DR. Allelic loss in a minimal region on chromosome 16q24 is associated with vitreous seeding of retinoblastoma. Cancer Research 2007, 67: 408-16
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• Raulf-Heimsoth M, Pesch B, Schott K, Kappler M, Preuss R, Marczynski B, Angerer J, Rihs HP, Hahn JU, Merget R, Bruning T. Irritative effects of fumes and aerosols of bitumen on the airways: results of a cross-shift study. Arch Toxicol 2007, 81(1): 35-44
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• Marczynski B, Raulf-Heimsoth M, Preuss R, Kappler M, Käfferlein HU, Schott K, Pesch B, Mensing T, Spickenheuer A, Angerer J, Brüning T. PAH metabolites in urine and genotoxic effects in white blood cells of mastic asphalt workers exposed to fumes and aerosols of bitumen in a cross-shift study. Tox Letters 2006, 164S: S282
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• Marczynski B, Raulf-Heimsoth M, Preuss R, Kappler M, Schott K, Pesch B, Zoubek G, Hahn JU, Mensing T, Angerer J, Kafferlein HU, Bruning T. Assessment of DNA damage in WBCs of workers occupationally exposed to fumes and aerosols of bitumen. Cancer Epidemiol Biomarkers Prev 2006, 15(4): 645-51
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• Nizri D, Boisnic S, Ben Slama L, Branchet C, Bervialle C, Roche S, Cassam-Chenaï A, Bergogne F, Kappler M, Atlan D. Clinical, histological and immunohistochemical evaluation of the protective effect of Biafine® on the secondary cutaneous effects during external, cervical radiotherapy. Bulletin Cancer 2006, 93(6): 619
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• Lammert M, Kappler M, Mautner VF, Lammert K, Störkel S, Friedman JM, Atkins D. Decreased bonemineral density in patients with neurofibromatosis 1. Osteoporosis Int, 2005, 16(9): 1161-6
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• Rihs HP, Pesch B, Kappler M, Rabstein S, Roßbach B, Angerer J, Scherenberg M, Adams A, Wilhelm M, Seidel A, Brüning T. Occupational exposure to PAH in German industries: Association between ambient exposure and urinary metabolites and its modulation by enzyme polymorphisms. Tox letters, 2005, 157(3): 241-55
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• Mensing T, Marczynski B, Engelhardt B, Wilhelm M, Preuss R, Kappler M, Angerer J, Käfferlein HU, Scherenberg M, Seidel A, Brüning T. DNA adduct formation of benzo[a]pyrene in white blood cells of workers exposed to PAH. Int J Hygiene Env Health, 2005, 208(3): 173-8
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• Marczynski B, Merget R, Mensing T, Rabstein S, Kappler M, Bracht A, Haufs MG, Käfferlein HU, Brüning T. DNA strand breaks in the lymphocytes of workers exposed to diisocyanates: indications of individual differences in susceptibility after low-dose and short-term exposure. Arch Toxicol, 2005, 79(6): 355-62
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• Kappler M. Presentation of a SAS macro for the documentation of programs in multi-user environments. Proceedings of the German conference for SAS users in research and development (KSFE), D Beyer, Ortseifen C (Ed.), Shaker Verlag, Aachen 2004 [in german]
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• Kappler M. News from the literature: "Modelling Smoking History: A Comparison of Different Approaches". Pneumologie, 2004, 58(2): 119ff [in german]
• Büsche G, Hehlmann R, Hecker H, Heimpel H, Heinze B, Schmeil A, Pfirrmann M, Gomez G, Tobler A, Herrmann H, Kappler M, Hasford J, Buhr T, Kreipe HH, Georgii A. Marrow fibrosis, indicator of therapy failure in chronic myeloid leukemia - prospective long-term results from a randomized-controlled trial. Leukemia, 2003, 17(12): 2444-53
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• Wispler M, Kappler M, Soto Vera D, Reif M, Schnelle M, Zänker KS. Prospective, randomised and semi-controlled clinical trial of the activation of homing and the general activation level of T-lymphocytes following a subcutaneous injection of mistletoe extract in healthy male subjects. Scheer R (Ed.), KVC-Verlag, Essen, 2005
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• Weihs C, Kappler M. e-stat: Development of a Scenario for Statistics in Chemical Engeneering. Proceedings in Computational Statistics, Härdle W, Rönz B (Ed.), Berlin, 2002
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• Sander P, Springer B, Prammananan T, Sturmfels A, Kappler M, Pletschette M, Bottger EC. Fitness cost of chromosomal drug resistance-conferring mutations. Antimicrob Agents Chemother 2002, 46(5): 1204-11
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• Krampfl K, Schlesinger F, Zorner A, Kappler M, Dengler R, Bufler J. Control of kinetic properties of GluR2 flop AMPA-type channels: impact of R/G nuclear editing. Eur J Neurosci, 2002, 15(1): 51-62
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• Bernhard W, Hoffmann S, Dombrowsky H, Rau GA, Kamlage A, Kappler M, Haitsma JJ, Freihorst J, von der Hardt H, Poets CF. Phosphatidylcholine molecular species in lung surfactant: composition in relation to respiratory rate and lung development. Am J Respir Cell Mol Biol, 2001, 25(6): 725-31
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Presentations

• Kappler M, Pesch B, Marczynski B, Rihs HP, Angerer J, Scherenberg M, Adams A, Seidel A, Wilhelm M, Bruning T. Dose-response relation of external and internal exposure as well as genotoxical effects in workers with exposure to PAH. Arbeitsmedizin, Sozialmedizin, Umweltmedizin 2006, 41(3):108
• Kappler M, Neuhäuser M, Raulf-Heimsoth M, Brüning T. A two-part permutation test in mixed models – Application on data of workers exposed to bitumen. Conference of the German epidemiological society (DGEpi) and the German society of medical computer science, biometry and epidemiology (GMDS), Freiburg, 2005/9/12-15
• Raulf-Heimsoth M, Liebig R, Merget R, Kappler M, Marczynski B, Heinze E, Brüning T. Non-invasive methods in the diagnosis of diisocyanate-induced asthma. World Allergy Congress, Munich, 2005/6/26 – 7/1
• Rihs HP, Pesch B, Kappler M, Rabstein S, Roßbach B, Angerer J, Scherenberg M, Adams A, Wilhelm M, Seidel A, Brüning T. Examinations on the effect of enzyme variants after occupational exposure to PAH. Conference of the German society for occupational and environmental medicine (DGAUM), Bochum, 2005/4/6-9
• Raulf-Heimsoth M, Schott K, Pesch B, Kappler M, Zoubek G, Angerer J, Merget R, Brüning T. Cross-shift study of the chemical irritative effects of fumes and aerosols of hot bitumen. DGAUM, Bochum, 2005/4/6-9
• Kappler M, Ortseifen C, Pfister G, Stürzl H. Tips and tricks for an easier use of SAS. German conference of SAS users in research and development (KSFE), Berlin, 2005/3/3-4
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• Kappler M, Pesch B, Rabstein S, Rihs HP, Brüning T. Modelling Genetic Polymorphisms: A Cross-Sectional Study of Occupational Exposure to PAH. Workshop: Statistical methods in medicine, clinical research and epidemiology, Halle (Saale), 2004/11/18-19
• Kappler M, Weihs C. Development of a statistic scenario in chemical engineering within the teaching and learning software EMILeA-stat. 1. Dortmund day of teaching and learning, Dortmund, 2002/2/7
• Kappler M, Hense A. Modelling the probability of precipitation using the Marcov Chain Monte Carlo technique. 8th International Meeting on Statistical Climatology, Lüneburg, 2001/3/12-16

Posters

• Kappler M, Gerss J. Bayesian Hypothesis Testing (BHT) in Single-arm Phase II Clinical Trials with Binary Endpoints. Joint Biometric Conference of the Austro-Swiss Region (ROeS), the German Region (DR) and the National Group Poland of the International Biometric Society (IBS), Zürich, 2011/9/12-15
• Gerss J, Kappler M. A Bayes method for test problems. The example of the homogeneity test to compare two success rates. Joint conference of the German Society for Medical Informatics, Biometry and Epidemiolgy (GMDS) and the German Epidemiological Society (DGEpi), Mainz, 2011/9/26-29
• Kappler M, Neuhäuser M, Raulf-Heimsoth M, Pesch B, Brüning T. An ad-hoc method for the analysis of observations below a limit of quantification – Simulation study and application to a dataset of occupational medicine. Colloquium of the Internation Biometric Society - German Region, Heidelberg, 2006 /3/6-8
• Marczynski B, Merget R, Mensing T, Rabstein S, Kappler M, Bracht A, Lee E-H, Haufs MG, Käfferlein HU, Brüning T. Detection of DNA strand breaks with the Comet-Assay in lymphocytes of workers exposed to diisocyanates. DGAUM, Bochum, 2005/4/6-9
• Welge P, Marczynski B, Raulf-Heimsoth M, Kappler M, Bracht A, Borowitzki G, Scherenberg M, Käfferlein HU, Wilhelm M, Seidel A, Angerer J, Brüning T. Detection of DNA strand breaks frequencies and micronuclei in lymphocytes of coke oven workers exposed to PAH. DGAUM, Bochum, 2005/4/6-9
• Marczynski B, Merget R, Mensing T, Rabstein S, Kappler M, Bracht A, Haufs MG, Käfferlein HU, Brüning T. DNA strand breaks in lymphocytes of workers exposed to diisocyanates: Indications of individual differences in susceptibility after short-term exposure. German society of experimental and clinical pharmacology and toxicology (DGPT), Mainz, 2005/3/15-17

• Raulf-Heimsoth M, Pesch B, Kappler M, Schott K, Schicker HJ, Zoubek G, Angerer J, Rumler R, Rühl R, Merget R, Brüning T. Cross-shift study of the health effects of bitumen fumes and aerosols under high processing temperatures. Annual Congress of the European Respiratory Society, Glasgow, 2004/9/4-8
• Ko Y, Baisch C, Brauch H, Brüning T, Hamann U, Harth V, Justenhoven C, Kappler M, Pesch B, Pierl C, Rabstein S. Hormon-replacement therapy and risk of breast cancer – first results of a German case-control study. 178th Conference of the Rhenish-Westphalian society for internal medicine, Leverkusen, 2003/11/7-8
• Pesch B, Rabstein S, Kappler M, Harth V, Pierl C, Brauch H, Hamann U, Justenhoven C, Ko Y, Brüning T. Hormone replacement therapy – results from a German population-based case-control study. 6th European Congress of Endocrinology, Lyon, 2003/4/26-30